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KMID : 0644320060110010031
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Journal of Korean Oriental Oncology
2006 Volume.11 No. 1 p.31 ~ p.39
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The Study on the Process and Quality Control of Rhus Verniciflua Stokes Extract (Nexia)
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Park Sang-Jae
Kim Kyung-Suk
Jung Hyun-Sik
Choi Won-Cheol
Yoon Seong-Woo
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Abstract
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Rhus Verniciflua Stokes has been used for long history to treat blood stasis and cancer in Oriental Medicine. But urushiol, a constituent of Rhus Verniciflua Stokes has T-cell mediated allergic reaction, so it has made clinical limitation. Nexia is allergen removed extract of Rhus Verniciflua Stokes and its extraction process as well as quality control is needed to be standardized. The optimized extraction condition is as follow; temperature is 90~95℃, volume of slovent 10 times, extraction time >6 hours, pressure $9.8(w/w). HPLC pattern and isolation study showed Nexia contain fisetin(>13.0%), fustin(>7.0%) and no urushiol.
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